University of Illinois at Chicago
Department of Psychiatry(MC 747)
1747 West Roosevelt Road,Rm 253,
Chicago, Illinois 60608

Office Phone: (312) 996-8568

E-mail:This email address is being protected from spambots. You need JavaScript enabled to view it.


Fang Liang, Minjie Wu, Shaolin Yang, “Adaptively optimized combination of magnetic resonance spectroscopy data from phased array coils”, Magnetic Resonance in Medicine, In Press.

Anand Kumar, Shaolin Yang, Olusola Ajilore, Minjie Wu, Jamie Cohen, Melissa Lamar, Dulal Bhaumik. Biophysical Changes in Subcortical Nuclei: Impact of Diabetes and Major Depression. Molecular Psychiatry. In Press.

Shaolin Yang, Olu Ajilore, Minjie Wu, Melissa Lamar, Anand Kumar, “Impaired macromolecular protein pools in fronto-striato-thalamic circuits in type 2 diabetes revealed by magnetization transfer imaging”, Diabetes, 2015 Jan;64(1):183-92.

Minjie Wu*, Lisa H. Lu, Allison Lowes, Shaolin Yang, Alessandra M. Passarotti, Xiaohong J. Zhou, Mani N. Pavuluri. “Development of Superficial White Matter and its Structural Interplay with Cortical Gray Matter in Children and Adolescent”,Human Brain Mapping, 2014 Jun;35(6):2806-16.

Anand Kumar, Shaolin Yang, Olu Ajilore, Minjie Wu, Rebecca Charlton, Melissa Lamar. “Subcortical biophysical abnormalities in patients with mood disorders”, Molecular Psychiatry, 19:710-716, 2014. PMCID: PMC4159940.

Minjie Wu*, Lisa H. Lu, Alessandra M. Passarotti, Ezra Wegbreit, Jacklynn Fitzgerald, Mani N. Pavuluri. “Altered affective, executive and sensorimotor resting state networks in patients with pediatric mania”, Journal of Psychiatry and Neuroscience, 38(4):232-240, 2013. PMCID: PMC3692720.

Hongyu Yang, Lisa H. Lu, Minjie Wu, Michael Stevens, Ezra Wegbreit, Jacklynn Fitzgerald, Bryn Levitan, Stewart Shankman, Mani N. Pavuluri. “Time Course of Recovery Showing Initial Prefrontal Cortex Changes at 16 weeks Extended to Subcortical Changes by Three years in Pediatric Bipolar Disorder”, Journal of Affective Disorders, 150(2):571-577, 2013. PMCID:PMC3745513.

Ezra Wegbreit, Alessandra M. Passarotti, James Ellis, Minjie Wu , Nichole Witowski , Jacklynn Fitzgerald, Michael Stevens, Mani N. Pavuluri. “Where, when, how high, and how long? The hemodynamics of emotional response in psychotropic-naïve patients with adolescent bipolar disorder”, Journal of Affective Disorders, 147(1-3):304-311, 2013. PMCID: PMC3606663.

Minjie Wu, Carmen Andreescu, Meryl A. Butters, Robert Tamburo, Charles F. Reynolds III, Howard J. Aizenstein. “Resting State Connectivity and White Matter Burden in Late-life Depression”. Psychiatry Research: NeuroImaging, 194(1):39-46, 2011. PMCID: PMC3189685.

Carmen Andreescu, Minjie Wu, Meryl Butters, Jennifer Figurski, Charles F. Reynolds III, Howard J Aizenstein. “The default mode network in late-life anxious depression”. American Journal of Geriatric Psychiatry. 19(11):980-983, 2011. PMCID:PMC3200466.

Howard J. Aizenstein, Meryl A. Butters, Minjie Wu, Laura M. Mazurkewicz, Andrew V. Stenger, Pete J. Gianaros, James T. Becker, Charles F. Reynolds III, Cameron S. Cater. “Altered Functioning of the Executive Control Circuit in Late-life Depression: Episodic and Persistent Phenomena”. American Journal of Geriatric Psychiatry, 17(1): 30-42, 2009. PMCID: PMC2626170.

Meryl A. Butters, Howard J. Aizenstein, Kiralee Hayashi, Carolyn C. Meltzer, Jamie Seaman, Charles F. Reynolds III, Arthur W. Toga, Paul M. Thompson, James T. Becker; IMAGe Research Group (Minjie Wu). “Three-dimensional Surface Mapping of the Caudate Nucleus in Late-life Depression”. American Journal of Geriatric Psychiatry, 17(1):4-12, 2009.

Minjie Wu, Lin-Ching Chang, Lindsay Walker, Herve Lemaitre, Alan. S. Barnett, Stefano Marenco, Carlo Pierpaoli. “Comparison of EPI Distortion Correction Methods in Diffusion Tensor MRI Using a Novel Framework”. Med Image Comput Comput Assist Interv, 11(Pt 2):321-9, 2008.

Carmen Andreescu, Meryl A. Butters, Peichang Shi, Amy Begley, Tarek Rajji, Minjie Wu, Carolyn C. Meltzer, Charles F. Reynolds III, Howard J. Aizenstein. “Gray Matter Changes in Late Life Depression - A Structural MRI Analysis”.Neuropsychopharmacology, 33(11): 2566-2572, 2008. PMCID: PMC2872084.

Caterina Rosano, Howard J. Aizenstein, Minjie Wu, Anne B. Newman, James T. Becker, Oscar L. Lopez, Lewis H. Kuller. “Focal Atrophy and Cerebrovascular Disease Increase Dementia Risk Among Cognitively Normal Older Adults”. Journal of Neuroimaging, 17(2): 148-155, 2007.

Minjie Wu, Caterina Rosano, Pilar Lopez-Garcia, Cameron S. Carter, Howard J. Aizenstein. “Optimum Template Selection for Atlas-based Segmentation”. NeuroImage, 34(4):1612-1618, 2007.

Minjie Wu, Caterina Rosano, Meryl Butters, Ellen Whyte, Megan Nable, Ryan Crooks, Carolyn C. Meltzer, Charles F. Reynolds III, Howard J. Aizenstein. “Automated Method for Quantifying and Localizing White Matter Hyperintensities on MR images”. Psychiatry Research: NeuroImaging, 148(2-3):133-142, 2006.

Minjie Wu, Owen T. Carmichael, Pilar Lopez-Garcia, Cameron S. Cater, Howard J. Aizenstein. “Quantitative Comparison of AIR, SPM, and the Fully Deformable Model for Atlas-based Segmentation of Functional and Structural MR Images”. Human Brain Mapping, 27(9):747-754, 2006. PMCID: PMC1761950.

Minjie Wu, PhD

Director of Neuroimaging Methods
Research Assistant Professor in Psychiatry

Dr. Wu is a Research Assistant Professor in the Department of Psychiatry of UIC and the Director of Neuroimaging Methods at the UIC Pediatric BRAIN Center. At the BRAIN Center, Dr. Wu is developing advanced functional and structural MR imaging techniques (including T1w, DTI, resting-state and task-evoked fMRI) and applying these techniques to characterize the developmental trajectories of normal brain maturation as well as the developmental perturbations or deviations in neuropsychiatric disorders. These include: map the abnormally engaged resting state affective, executive, and sensorimotor networks in psychotropic naïve patients with pediatric mania using resting state fMRI; probe the affective and cognitive abnormalities in pediatric psychiatric disorders using GLM-based and ICA-based functional connectivity methods on task-evoked fMRI; identify structural abnormalities in major white matter bundles and cortical gray matter in pediatric bipolar disorder.

During her Ph.D. training in Bioengineering at the University of Pittsburgh, Dr. Wu worked at the Geriatric Psychiatry Neuroimaging Lab of the Western Psychiatric Institute and Clinic (WPIC), during which she developed MR imaging algorithms including Automated Labeling Pathway (ALP) for brain image segmentation, automated white matter hyperintensity (WMH) segmentation and localization algorithms, and Optimum MRI Template Selection method for more accurate brain image segmentation/normalization. Using resting-state fMRI, Dr. Wu found altered default-mode network in late-life depression compared to controls. During her curricular practical training in the Section on Tissue Biophysics & Biomimetics (STBB), National Institute of Child Health & Human Development (NICHD)/National Institutes of Health (NIH), Dr. Wu developed the image-registration based EPI distortion correction algorithm for DTI data processing, which is included in the NIH diffusion MRI data processing software package: TORTOISE. During her post-doctoral training at the Department of Neurology, Northwestern University, Dr. Wu used high resolution DTI and resting state connectivity analysis method to study Parkinson's disease.


  • International Society for Magnetic Resonance in Medicine
  • Organization for Human Brain Mapping


Resting state fMRI, diffusion tensor imaging, task-based fMRI, multi-modality imaging fusion, graph theory, machine learning, normal brain development, pediatric bipolar disorder, and late-life depression.


You are here: Home Faculty ABOUT US Directory Faculty Minjie Wu, PhD