Genomic Studies

Principal Investigator
Mani Pavuluri, MD, PhD

Goal 1: To characterize the relationship between the SLC6A4 5HTTLPR and BDNF Val66Met variants with cognitive and affective circuitry dysfunction in PBD.

Goal 2: To determine whether changes in clinical symptoms, brain function, and cognitive performance seen after lithium treatment differ across 5HTTLPR and BDNF genotype groups.

Goal 3: To conduct a discovery set GWAS analysis of targeted fMRI and eye movement phenotypes to identify additional genetic contributors to cognitive processing and treatment response to Li+ in PBD.

FUNDING: NIMH 5R01MH081019-02


The Brain Center and the clinic is a part of the Pediatric Mood Disorders Program, The Colbeth Child and Adolescent Psychiatry Clinic, the Institute for Juvenile Research, and the Department of Psychiatry at the University of Illinois at Chicago.


1747 West Roosevelt Road
Suite 155, M/C 747
Chicago, IL 60608
Phone: (312) 996-7723
Fax: (312) 413-0063


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