Principal Investigator
Rachel Jacobs, PhD

Currently, approximately 50% of individuals who experience depression during their adolescence experience depression again. No current treatments protect against the lifelong consequences of depression in one’s youth. This project seeks to therapeutically modulate the brain circuitry underlying rumination, a passive and maladaptive thought pattern, for the purposes of reducing risk for the recurrence of depression in adolescents. In addition to assessing the impact of a novel relapse prevention program (rumination specific emotion regulation; RER); this study will examine the impact of rumination on the neural systems implicated in emotion regulation among adolescents. RER has recently been tested in the prevention of first-onset depression among adolescent girls, with an observed decrease in depression scores of approximately 30%. In applying RER to the prevention of recurrent depression, I hypothesize that RER will result in reductions in ruminative tendencies as well as normalized patterns in brain regions associated with depression and rumination when compared to adolescents in an assessment only condition. I also hypothesize that RER will result in lower rates of depression relapse and decreases in residual depression symptoms.

FUNDING: Klingenstein Third Generation Foundation


The Brain Center and the clinic is a part of the Pediatric Mood Disorders Program, The Colbeth Child and Adolescent Psychiatry Clinic, the Institute for Juvenile Research, and the Department of Psychiatry at the University of Illinois at Chicago.


1747 West Roosevelt Road
Suite 155, M/C 747
Chicago, IL 60608
Phone: (312) 996-7723
Fax: (312) 413-0063


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