Dept. of Psychiatry,
University of Illinois at Chicago
1747 W. Roosevelt Rd., WROB/IJR Rm. 244, Chicago, IL 60608,
SELECT KEY PUBLICATIONS:
Crane, N.A., Jenkins, L.M., Dion, C., Meyers, K.K., Weldon, A.L., Gabriel, L.B., Walker, S.J., Hsu, D.T., Noll, D.C., Klumpp, H., Phan, K.L., Zubieta, J-K., & Langenecker, S.A. (in press). Comorbid Anxiety Increases Cognitive Control Activation in Major Depressive Disorder. Depression and Anxiety.
Jacobs, R.H., Barba, A., Gowins, J.R., Klumpp, H., Jenkins, L., Mickey, B.J., Ajilore O., Pecina, M., Sikora, M., Ryan, K.A., Hsu, D.T., Welsh, R.C., Zubieta, J.K., Phan, K.L., & Langenecker, S.A. (2016). Decoupling of the amygdala to other salience network regions in adolescent onset recurrent major depressive disorder. Psychological Medicine
MacNamara A, Rabinak CA, Kennedy A, Fitzgerald DA, Stein MB, Liberzon I, Phan KL (2016). Emotion regulatory brain function and SSRI treatment in PTSD: Neural correlates and predictors of change. Neuropsychopharmacology 41(2):611-8.
Kujawa A, Swain JE, Koschmannn E, Simpson D, Connolly S, Fitzgerald KD, Monk CS, Phan KL (2016). Prefrontal Reactivity to Social Signals of Threat as a Predictor of Treatment Response in Anxious Youth. Neuropsychopharmacology 41(8):1983-90.
Klumpp H, Fitzgerald DA, Piejko K, Roberts J, Kennedy A, Phan KL (2016). Prefrontal Control and Predictors of Cognitive Behavioral Therapy Response in Social Anxiety Disorder. Social Cognitive Affective Neuroscience 11(4):630-40.
Wu M, Kujawa A, Lu LH, Fitzgerald DA, Klumpp H, Fitzgerald KD, Monk CS, Phan KL (2016). Age-related changes in amygdala-frontal connectivity during emotional face processing from childhood into young adulthood. Human Brain Mapping 37(5):1684-95.
Gorka SM, Fitzgerald DA, Labuschagne I, Hosanagar A, Wood A, Nathan PJ, Phan KL (2015). Oxytocin Modulation of Amygdala Functional Connectivity to Fearful Faces in Generalized Social Anxiety Disorder. Neuropsychopharmacology 40(2):278-86
Rabinak CA, Angstadt MLyson M, Mori S, Milad MR, Liberzon I, Phan KL (2014). Cannabinoid modulation of prefrontal-limbic activation during fear extinction learning and recall in humans. Neurobiology of Learning and Memory 113:125-34.
Phan KL, Coccaro EF, Angstadt M, Kreger KJ, Mayberg HS, Liberzon I, Stein MB (2013). Corticolimbic Brain Reactivity to Social Signals of Threat Before and After Sertraline Treatment in Generalized Social Phobia. Biological Psychiatry 73(4):329-36.
Kim P, Evans GW, Angstadt M, Ho SS, Sripada CS, Swain JE, Liberzon I, Phan KL (2013).Effects of childhood poverty and chronic stress on emotion regulatory brain function in adulthood. Proceedings of the National Academy of Sciences (PNAS) 110(46):18442-7
Maren S, Phan KL, Liberzon I (2013). The Contextual Brain: Implications for Fear Conditioning, Extinction, and Psychopathology. Nature Reviews Neuroscience 14(6):417-28 1.
Phan KL, Sripada CS, Angstadt M, McCabe K (2010). Reputation for reciprocity engages the brain’s reward center. Proceedings of the National Academy of Sciences (PNAS) 107(29):13099-104.
Phan KL, Angstadt M, Golden J, Onyewuenyi I, Popovska A, de Wit H (2008). Cannabinoid Modulation of Amygdala Reactivity to Social Signals of Threat in Humans. Journal of Neuroscience 28(10):2313-2319.
Banks S, Eddy K, Angstadt M, Nathan PJ, Phan KL (2007). Amygdala-frontal connectivity during emotion regulation. Social Cognitive Affective Neuroscience 2: 303-312.
Phan KL, Fitzgerald DA, Nathan PJ, Tancer ME (2006). Association between amygdala hyperactivity to harsh faces and severity of social anxiety symptoms in generalized social phobia. Biological Psychiatry 59:424-429.
Phan KL, Taylor SF, Fig LM, Britton JC, Liberzon I (2006). Corticolimbic blood flow during non-traumatic emotional processing in posttraumatic stress disorder. Archives of General Psychiatry 63:184-192.
K. Luan Phan, MD
Professor of Psychiatry
Dr. K. Luan Phan is Director of the Mood and Anxiety Disorders Research Program and Associate Head for Clinical and Translational Research in the Department of Psychiatry at the University of Illinois at Chicago. He is also Chief of NeuroPsychiatric Research and a VA Research Scientist at the Jesse Brown VA Medical Center. He is an adjunct faculty of Psychology, Anatomy and Cell Biology, and in the Graduate Program in Neuroscience. He has a longstanding commitment to translate discoveries from affective and cognitive neuroscience to improve our understanding and treatment of anxiety and mood disorders.
Lab/Research Program website: http://www.psych.uic.edu/research/mood-and-anxiety-disorders-research-program
Patient-oriented research in his interdisciplinary Research Program crosses both UIC and the VA and aims to discover the behavioral and brain mechanisms that implement the regulation of affect and motivational salience in humans. Using these discoveries of mechanisms, his group defines the brain targets to make treatments better and to innovate new interventions for mood and anxiety disorders. The Research Program integrates affective, cognitive, and social neuroscience perspectives and uses a multi-level, multi-unit analytic approach that integrates self-report and clinical scales, neuropsychological performance, behavior, neuropsychopharmacology, peripheral and central psychophysiology. In addition our studies involve children and adults and often incorporates clinical trials of pharmacotherapy and psychosocial interventions and a longitudinal design, from risk to illness to recovery. The Program primarily uses magnetic resonance imaging (fMRI, DTI, sMRI), electroencephalography (EEG) of event-related potentials (ERP) as predominant tools to assess brain circuit function as they relate to emotion, affect regulation, motivation and cognition. The Program appreciates that individual differences in brain function has a major influence on a person’s risk for - and resilience from - illness and on which treatment approach is most likely to promote recovery. The Program aims to answer three main questions: 1) What are the nodes of brain dysfunction in mood, anxiety and addiction disorders?; 2) How do treatments work and for whom?; and 3) Where and how do exogenous neuromodulatory agents (e.g., drugs of abuse, hormones, direct current stimulation) exert their effects on brain and behavior.
Dr. Phan received his medical degree from the University of Michigan in Ann Arbor and received psychiatry residency and research track training at the Western Psychiatric Institute and Clinics at the University of Pittsburgh and at the University of Michigan Hospitals and Clinics. Prior to joining the faculty at the University of Illinois at Chicago in 2012, he was Associate Professor in the Department of Psychiatry and Neuroscience Program at the University of Michigan and Chief of the Mental Health Clinic at the Ann Arbor VA Healthcare System.
In 2011, Dr. Phan was awarded the Presidential Early Career Award for Scientists and Engineers (PECASE), the highest honor bestowed by the United States government on outstanding scientists and engineers in the early stages of their independent research career. Dr. Phan’s research has been consistently funded by the National Institutes of Health, Veterans Affairs, and Department of Defense over the past 15 years. He has over 150 peer-reviewed publications, in journals such as Archives of General Psychiatry, Biological Psychiatry, American Journal of Psychiatry, Neuropsychopharmacology, Proceedings of the National Academy of Sciences, and Journal of Neuroscience. Dr. Phan has served as editor and on editorial boards for several journals and peer reviewer on several NIH, DoD, and VA study sections. He has been a member of the Scientific Council of the Anxiety and Depression Association of America, and the Scientific Program Committee of the Society of Biological Psychiatry. He has been selected as a Member of the American College of Neuropsychopharmacology (ACNP).
1) Functional Neuroanatomy of Emotion, Cognition, and Motivation
2) Functional Neuroanatomy Mood and Anxiety Disorders and Addiction
3) Brain Mechanisms and Predictors of Treatment Response in Mood and Anxiety Disorders
4) Functional Neuroimaging of Drug Effects on Affective Experience and Cognition