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K. Luan Phan, MD


Dept. of Psychiatry,
University of Illinois at Chicago
1747 W. Roosevelt Rd., WROB/IJR Rm. 244, Chicago, IL 60608,

E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.



Burkhouse KL, Gorka SM, Klumpp H, Kennedy AE, Karich S, Francis J, Ajilore O, Craske MG, Langenecker S, Shankman SA, Hajcak G, Phan, KL (in press). Neural responsiveness to reward as an index of depressive symptom change following cognitive-behavioral therapy and selective serotonin reuptake inhibitor treatment. The Journal of Clinical Psychiatry

Gorka SM, Lieberman L, Shankman SA, Phan KL (2017). Startle Potentiation to Uncertain Threat as a Psychophysiological Indicator of Fear-based Psychopathology: An Examination across Multiple Internalizing Disorders.  Journal of Abnormal Psychology 126(1):8-18.

DiGangi JA, Gorka SM, Afshar K, Babione JM, Schroth C, Greenstein JE, Proescher E, Dolcos F, Phan KL (2018). Differential Impact of Post-Deployment Stress and PTSD on Neural Reactivity to Emotional Stimuli in Iraq and Afghanistan Veterans. Journal of Psychiatric Research  96:9-14.

Wu M, Kujawa A, Lu LH, Fitzgerald DA, Klumpp H, Fitzgerald KD, Monk CS, Phan KL (2016). Age-related changes in amygdala-frontal connectivity during emotional face processing from childhood into young adulthood. Human Brain Mapping

MacNamara A, Rabinak CA, Kennedy A, Fitzgerald DA, Stein MB, Liberzon I, Phan KL (2016).  Emotion regulatory brain function and SSRI treatment in PTSD: Neural correlates and predictors of change. Neuropsychopharmacology 41(2):611-8.

Kujawa A, Swain JE, Koschmannn E, Simpson D, Connolly S, Fitzgerald KD, Monk CS, Phan KL (2016).  Prefrontal Reactivity to Social Signals of Threat as a Predictor of Treatment Response in Anxious Youth. Neuropsychopharmacology

Klumpp H, Fitzgerald DA, Piejko K, Roberts J, Kennedy A, Phan KL (2016). Prefrontal Control and Predictors of Cognitive Behavioral Therapy Response in Social Anxiety Disorder. Social Cognitive Affective Neuroscience

Gorka SM, Fitzgerald DA, Labuschagne I, Hosanagar A, Wood A, Nathan PJ, Phan KL (2015). Oxytocin Modulation of Amygdala Functional Connectivity to Fearful Faces in Generalized Social Anxiety Disorder. Neuropsychopharmacology 40(2):278-86

Rabinak CA, Angstadt MLyson M, Mori S, Milad MR, Liberzon I, Phan KL  (2014). Cannabinoid modulation of prefrontal-limbic activation during fear extinction learning and recall in humans. Neurobiology of Learning and Memory 113:125-34.

Phan KL, Coccaro EF, Angstadt M, Kreger KJ, Mayberg HS, Liberzon I, Stein MB (2013). Corticolimbic Brain Reactivity to Social Signals of Threat Before and After Sertraline Treatment in Generalized Social Phobia.  Biological Psychiatry 73(4):329-36.

Kim P, Evans GW, Angstadt M, Ho SS, Sripada CS, Swain JE, Liberzon I, Phan KL (2013).Effects of childhood poverty and chronic stress on emotion regulatory brain function in adulthood. Proceedings of the National Academy of Sciences (PNAS) 110(46):18442-7

Maren S, Phan KL, Liberzon I (2013). The Contextual Brain: Implications for Fear Conditioning, Extinction, and Psychopathology. Nature Reviews Neuroscience 14(6):417-28 1.

Phan KL, Sripada CS, Angstadt M, McCabe K (2010). Reputation for reciprocity engages the brain’s reward center. Proceedings of the National Academy of Sciences (PNAS) 107(29):13099-104.

Phan KL, Angstadt M, Golden J, Onyewuenyi I, Popovska A, de Wit H (2008). Cannabinoid Modulation of Amygdala Reactivity to Social Signals of Threat in Humans. Journal of Neuroscience 28(10):2313-2319.

Banks S, Eddy K, Angstadt M, Nathan PJ, Phan KL (2007).  Amygdala-frontal connectivity during emotion regulation.   Social Cognitive Affective Neuroscience 2: 303-312.

Phan KL, Fitzgerald DA, Nathan PJ, Tancer ME (2006).  Association between amygdala hyperactivity to harsh faces and severity of social anxiety symptoms in generalized social phobia.  Biological Psychiatry 59:424-429.

Phan KL, Taylor SF, Fig LM, Britton JC, Liberzon I (2006).  Corticolimbic blood flow during non-traumatic emotional processing in posttraumatic stress disorder.  Archives of General Psychiatry 63:184-192.

K. Luan Phan, MD

Professor of Psychiatry

Dr. K. Luan Phan is the UI CDR Endowed Professor, Director of the Mood and Anxiety Disorders Research Program (MADRP) and Associate Head for Clinical and Translational Research in the Department of Psychiatry at the University of Illinois at Chicago.  He is also Chief of NeuroPsychiatric Research and a VA Research Scientist at the Jesse Brown VA Medical Center.  He has a longstanding commitment to translate discoveries from affective and cognitive neuroscience to improve our understanding and treatment of anxiety and mood disorders.

Lab/Research Program website: https://education.psych.uic.edu/research/lab-directory/madrp-phan-lab

Patient-oriented research in his interdisciplinary Research Program crosses both UIC and the VA and studies variations of psychopathology and health from an affective neuroscience perspective (phan Lab). His team understands that emotions have a powerful role in tuning our perception, imbuing our experience, guiding our decisions, and shaping our actions. As such, they believe that anxiety, fear, depression, addiction, obsessions and compulsions can be understood along dimensions of emotion that evolve over the lifespan and fluctuate with stress. They use neuroscience measures and methods to study the emotional brain and its readouts in the laboratory and the real world, and marry this approach with psychopharmacology, neuromodulation and intervention trials. The team primarily uses magnetic resonance imaging (fMRI, DTI, sMRI), electroencephalography (EEG) of event-related potentials (ERP), and other psychophysiological tools to assess brain circuit function as they relate to emotion, affect regulation and motivation. Their work seeks to better understand the neuropathophysiology and course of psychopathology, and to innovate strategies to prevent and treat more patients better and faster and keep them well for longer periods of time.

Dr. Phan received his medical degree from the University of Michigan in Ann Arbor and received psychiatry residency and research track training at the Western Psychiatric Institute and Clinics at the University of Pittsburgh and at the University of Michigan Hospitals and Clinics.  Prior to joining the faculty at the University of Illinois at Chicago in February 2012, he was Associate Professor in the Department of Psychiatry and Neuroscience Program at the University of Michigan and Chief of the Mental Health Clinic at the Ann Arbor VA Healthcare System.

Dr. Phan has been awarded the Presidential Early Career Award for Scientists and Engineers (PECASE), the highest honor bestowed by the United States government on outstanding scientists and engineers in the early stages of their independent research career. Dr. Phan’s research has been consistently funded by the National Institutes of Health, Veterans Affairs, and Department of Defense over the past 15 years.  He has over 200 peer-reviewed publications, in journals such as Archives of General Psychiatry, Biological Psychiatry, American Journal of Psychiatry, Neuropsychopharmacology, Proceedings of the National Academy of Sciences, Journal of Neuroscience, and Nature Reviews Neuroscience. Dr. Phan has served as editor and on editorial boards for several journals and peer reviewer on several NIH, DoD, and VA study sections. He has been a member of the Scientific Council of the Anxiety and Depression Association of America, and the Scientific Program Committee of the Society of Biological Psychiatry. He has been selected as a Felllow of the American College of Neuropsychopharmacology (ACNP).


Research Themes:
1)  Functional Neuroanatomy of Emotion, Cognition, and Motivation
2)  Functional Neuroanatomy Anxiety, Mood and Addiction Disorders
3)  Brain Mechanisms and Predictors of Treatment Response in Mood and Anxiety Disorders
4)  Functional Neuroimaging of Drug Effects on Emotion and Cognition


  1. Ambulatory Clinic:
    Neuropsychiatric Insitute
    912 S. Wood Steet, Chicago, IL 60612
  2. UIC Hospital
    1740 W Taylor St, Chicago, IL 60612
  3. Institute for Juvenile Research
    1747 W. Roosevelt Rd, Chicago, IL 60608
  4. Psychiatric Institute
    1601 W. Taylor St.Chicago, IL 60612

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