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Amynah Pradhan PhD

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KEY PUBLICATIONS

A.A. Pradhan, M. Smith, B. McGuire, I. Tarash, C. Evans, and A. Charles. (2013) Characterization of a Novel Model of Chronic Migraine. Pain Oct. 9

A.A. Pradhan, M. Smith, B. McGuire, C.Evans, and W.Walwyn. (2013) Chronic inflammatory Injury results in increased coupling of delta opioid receptors to voltage gated Ca2+ channels. Molecular Pain. 9:8.

A.A. Pradhan, M. Smith, B. Kieffer, and C. Evans. (2012) Ligand-directed signaling within the opioid receptor family. British Journal of Pharmacology. 167(5):960-9.

A.A. Pradhan, K. Befort, C. Nozaki, C. Gavériaux-Ruff, and B.L. Kieffer. (2011) The delta opioid receptor: an emerging target for brain disorders. Trends in Pharmacological Sciences. 32(10):581-90.

A.A. Pradhan, W. Walwyn, C.Nozaki, D. Filliol, E.Erbs, A. Matifas, C.Evans, and B. L. Kieffer. (2010) Ligand-directed trafficking of the delta opioid receptor in vivo: two distinct paths to analgesic tolerance. Journal of Neuroscience. 30(49):16459-68.

A.A. Pradhan, X.H. Yu, & J.M. Laird. (2009) Modality of hyperalgesia tested, not type of nerve damage, predicts pharmacological sensitivity in rat models of neuropathic pain. European Journal of Pain. 14(5):503-509.

A.A. Pradhan, J.A. Becker, G. Scherrer, P. Tryoen-Toth, D. Filliol, A. Matifas, D. Massotte, C. Gavériaux-Ruff, and B. L. Kieffer. (2009) In vivo delta opioid receptor internalization controls behavioral effects of delta agonists. PLoS ONE. 4(5):e5425.

C. Ndong* A.A. Pradhan*, C. Puma, J.P. Morello, T. Groblewski, D. O’Donnell and J.M. Laird. (2009) Role of rat Sensory Neuron Receptor (rSNSR1) in inflammatory pain: contribution of TRPV1 to SNSR signaling in the pain pathway. Pain. 143: 130-7.

A.A. Pradhan, Siau C, Constantin, and P.B.S. Clarke. (2006). Chronic morphine administration results in tolerance to delta opioid receptor-mediated antinociception. Neuroscience. 141:947-54.

A.A. Pradhan, and P.B.S. Clarke. (2005). Pharmacologically selective block of mu opioid antinociception by peptide nucleic acid antisense in absence of detectable ex vivo knockdown. European Journal of Pharmacology. 506: 229-246.

A.A. Pradhan, and P.B.S. Clarke. (2005). Comparison between delta opioid receptor functional response and autoradiographic labelling in rat brain and spinal cord. Journal of Comparative Neurology. 481: 416-426.

 

Amynah Pradhan PhD

Assistant Professor

Dr. Pradhan’s research focuses on the neuropharmacology of opioid receptors. She received her PhD in Pharmacology and Therapeutics from McGill University, where she studied the behaviorally relevant populations of mu and delta opioid receptors, and interactions between them. Dr. Pradhan then did a postdoctoral fellowship at AstraZeneca Montreal, where she helped characterize a novel protein involved with pain processing. During her subsequent fellowship at the Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC) in Strasbourg, France, she pursued her interest in the behavioral consequences of delta opioid receptor trafficking and signaling. Immediately prior to joining the faculty of UIC, Dr. Pradhan was a postdoctoral fellow at the University of California Los Angeles, where she explored the role of beta-arrestin scaffold proteins on delta opioid receptor signaling. During this time, she also developed an interest in the role of opioid receptors in migraine.

Interests:

Dr. Pradhan studies the neurobiology of opioid receptors. In particular, her lab seeks to elucidate the cellular signaling events that regulate behavioral effects of delta opioid receptor activation. Her lab is also conducting research exploring the role of opioid receptors in migraine. Overall, Dr. Pradhan aims to translate in vitro findings to animal behavioral models, with the ultimate goal of translating those results to clinical applications, particularly for the treatment of emotional disorders and pain.

 Projects:

NIH/NIDA In vivo implications of ligand-specific activation of delta opioid receptor.Neurobiology of Migraine

 

 

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