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Mani Pavuluri, MD, PhD

CONTACT INFORMATION

912 South Wood St. (M/C 913)
Chicago, IL 60612

Office Phone: (312) 413-1722
Office Fax: (312) 413-0063
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

Assistant: Rupal Satra, (312) 413-1722, This email address is being protected from spambots. You need JavaScript enabled to view it.

KEY PUBLICATIONS

Pavuluri MN, Passarotti A. Emotion Processing in Pediatric Bipolar Disorder, Expert Review of Neurotherapeutics, in press

Pavuluri MN, Oconnor-Marlow M, Harral E, Sweeney JA. An fMRI study of the interface between affective and cognitive neural circuitry in pediatric bipolar disorder, Psychiatric Research-Neuroimaging, 2008,162 (3): 244-255.

Pandey GN, Dwivedi Y, Pavuluri M. Decreased Protein Kinase C (PKC) in Platelets of Pediatric Bipolar Patients: Effect of Treatment with Mood Stabilizing Drugs, Journal of Psychiatric Research, 2008: 42: 106-116.

West AE, Pavuluri MN. Maintenance model of integrated psychosocial treatment in pediatric bipolar disorder, Journal of the American Academy of Child and Adolescent Psychiatry, 2007, 46 (2), 205-212

Pavuluri MN, Oconnor-Marlow M, Harral E, Sweeney JA. Role of the Affective Circuitry during Facial Emotion Processing in Pediatric Bipolar Disorder, Biological Psychiatry, 2007, 62:158-167

Schenkel LS, Pavuluri MN, Harral EM, and Sweeney JA. Facial Emotion Processing in Medicated and Unmedicated Patients with Pediatric Bipolar Disorder, Journal of American Academy of Child and Adolescent Psychiatry, 2007, 46(8):1070-1079

Pavuluri MN, Henry D, Nadimpalli S, O’Connor-Marlow M, Sweeney JA. Biological risk factors in pediatric bipolar disorder, Biological Psychiatry, 2006, 60 (9): 936-941

Pavuluri MN, O’Connor-Marlow M, Harral E, Moss M, Sweeney JA. Impact of Neurocognitive Function on Academic Difficulties in Pediatric Bipolar Disorder: A Clinical Translation, Biological Psychiatry, 2006, 60 (9): 951-956

Pavuluri MN, Henry D, Sampson G, Carbray J, Naylor M, Janicak PG. Risperidone augmentation of lithium in youth with a history of preschool onset bipolar disorder, Journal of Child and Adolescent Psychopharmacology, 2006, Vol 16, 3:336-350

Pavuluri MN, Henry D, Devineni B, Carbray J, Birmaher B. Child Mania Rating Scale: Development, Reliability and Validity, Journal of American Academy of Child and Adolescent Psychiatry, 2006, 45:550-560

Pavuluri MN, Schenkel LS, Aryal S, Harral E, S. Hill SK, Herbener ES, Sweeney JA. Neurocognitive function in unmedicated manic and medicated euthymic pediatric bipolar patients, American Journal of Psychiatry, 2006, 163: 286-293

Pavuluri MN, Birmaher B., Naylor M. Pediatric Bipolar Disorder: Ten Year Review, Journal of American Academy of Child and Adolescent Psychiatry, 2005, 44 (9): 846-871

Pavuluri MN, Herbener EC, Sweeney JA. Affect Regulation: A systems neuroscience perspective, Neuropsychiatric Disease and Treatment, 2005: 1(1)9-15

Pavuluri MN, Henry D, Naylor M, Carbray J, Sampson G, Janicak PG. A Pharmacotherapy Algorithm for Stabilization and Maintenance of Pediatric Bipolar Disorder, Journal of American Academy of Child and Adolescent Psychiatry, 2004, 43 (7): 859-867

Pavuluri MN, Grayczyk P, Carbray J, Heidenreich J, Henry D, Miklowitz D. Child and Family Focused Cognitive Behavior Therapy in Pediatric Bipolar Disorder, Journal of American Academy of Child and Adolescent Psychiatry, 2004, 43: 528-537

Pavuluri MN, Birmaher B. A Practical Guide to Using Ratings of Depression and Anxiety in Child Psychiatric Practice. Current Psychiatry Report. 2004; 6 (2) 108-116

Pavuluri MN, Luk SL, McGee R. Parent Reported Preschool Attention Deficit Hyperactivity: Measurement and Validity. European Journal of Child and Adolescent Psychiatry. 1999; 8:126-133

Mani Pavuluri, MD, PhD

Berger-Colbeth Chair in Child Psychiatry
Professor in Psychiatry

Mani Pavuluri is MD, PhD, Professor at the University of Illinois at Chicago (UIC), Berger-Colbeth Chair in Child Psychiatry, and Director of the Pediatric Brain Research And InterventioN (BRAIN) Center.

Dr. Pavuluri is trained as a Psychiatrist and Child Psychiatrist at Otago University Medical School in New Zealand, Royal Children’s Hospital at Melbourne University in Australia and the Australian and New Zealand College of Psychiatrists. During her Psychiatry training, she simultaneously completed her PhD in Developmental Psychopathology. She trained also at Rush University in Chicago and via an NIH K award training in functional neuroimaging (fMRI) and effects of medicine on brain function in children with mood disorders at UIC. She is Board certified in General and Child Psychiatry Training in Australia, New Zealand, and the United States.

Dr. Pavuluri is a member of the American College of Neuropsychopharmacology and has received many awards that include the prestigious Klingenstein Third Generation Award from AACAP for the best paper in mood disorders in 2009 and Gerry Klerman Award for outstanding research in 2010 from Brain and Behavior Research Foundation (NARSAD). She is the Founding Director of the now nationally recognized Pediatric Mood Disorders Clinic that grew into the Pediatric BRAIN Center at UIC. The program draws from 28 states to-date and has helped set up many programs across the world. She serves on the editorial Board of several top journals and published widely. She is funded by several granting agencies that include the National Institute of Mental Health (NIMH), National Institute of Child Health and Human Development (NICHD), NARSAD, Dana Foundation, Marshall Reynolds Foundation, American Foundation for Suicide Prevention (AFSP) and her grateful families. She is listed under Top Psychiatrists in America, selected by patients, and Best Doctors of America, selected by peers.

Her goal is to understand brain mechanisms in order to develop molecular and brain biosignatures of pediatric mood disorders and unravel how treatments can reverse brain dysfunction, working towards personalized interventions. She is working on suicide prevention and differentiating bipolar disorder from attention-deficit hyperactivity disorder (ADHD). Dr. Pavuluri’s work is the foremost among the cohort of studies mapping the interfacing affective and cognitive brain circuits. Her team’s work involving fMRI studies of the medication effects on brain function in pediatric bipolar disorder is considered a trail blazer in the field.

Affiliations/Memberships:

  • Member: American Academy of Child and Adolescent Psychiatry (AACAP)
  • Research Work Group of AACAP
  • Editorial Board of JAACAP
  • Child and Adolescent Bipolar Foundation Parent Advisory Council

Interests:

Dr. Pavuluri has obtained several grants, one of which is a K23 award from NIH looking at fMRI outcome pre- and post-clinical trial in pediatric bipolar disorder, followed by RO1 from NIMH in looking at the affects of lithium on brain function.

Her main area of interest is mapping brain circuits involved in emotion regulation and cognitive function and how they interact and influence daily life in pediatric bipolar patients. Inherent to this question is to understand how development and medications influence brain function.  

Projects:

  • Pediatric Bipolar Disorder: Randomized Controlled Trial of Risperidone vs Divalproex Sodium and fMRI Assessment of Relevant Affective Circuitry Pre and Post Treatment (collaborative efforts on projects listed below are built into professional and career development strategies intrinsic to this effort)
    There are two purposes for this project: 1) to determine whether risperidone is better than divalproex sodium in treating/stabilizing pediatric bipolar disorder. 2) to look at the dysfunction in brain activity before treatment, and to look for any alteration after treatment with either risperidone or divalproex sodium.
  • Collaborative Lithium Trials (COLT): Pharmacokinetic trial followed by acute, discontinuation and follow up trials; Multi site grant PI: Dr. R. Findling.
    This is a multiphase, multicenter, trial that will comprehensively examine lithium in the treatment of pediatric patients with bipolar I disorder. Dr. Pavuluri is the Site PI.
  • fMRI and Neurocognitive Effects, Safety and Efficacy of Lamotrigine in Pediatric Bipolar Disorder (Investigator initiated study)
    The aim of the study is to understand the treatment effects of lamotrigine on neurocognitive function and the affective and cognitive circuitry interface in Pediatric Bipolar Disorder.
  •  fMRI Study of Brain Circuitry Underlying Impulsivity and Affect Regulation in Suicidal Patients with Adolescent Bipolar Disorder
    The goal of the study is to map the brain circuitry in high risk patients with adolescent bipolar disorder to unravel the two most important factors of impulsivity and negative emotion regulation that are known to lead to completed suicide.
  • Connectivity between White and Gray Matter Abnormalities in Pediatric Bipolar Disorder: A Developmental Model of Brain Pathophysiology
    The goal of the study is to characterize cognitive and affective circuitry dysfunction in order to delineate the pathophysiology of PBD using functional magnetic resonance imaging (fMRI) technology.
  • Affective Neuroscience of Pediatric Bipolar Disorder
    The aim of this study is to enhance understanding of brain system dysfunction in pediatric bipolar disorder using fMRI and neurocognitive studies in an integrated approach.

Directions

Address:

  1. Ambulatory Clinic:
    Neuropsychiatric Insitute
    912 S. Wood Steet, Chicago, IL 60612
  2. UIC Hospital
    1740 W Taylor St, Chicago, IL 60612
  3. Institute for Juvenile Research
    1747 W. Roosevelt Rd, Chicago, IL 60608
  4. Psychiatric Institute
    1601 W. Taylor St.Chicago, IL 60612

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